Gynecological Oncology Studies - OCSRI

NRG GY026

This phase II/III trial tests whether adding trastuzumab and hyaluronidase-oysk (Herceptin HylectaTM) or pertuzumab, trastuzumab and hyaluronidase-zzxf (PhesgoTM) to the usual chemotherapy (paclitaxel and carboplatin) works to shrink tumors in patients with HER2 positive endometrial serous carcinoma or carcinosarcoma.

Phase II, Phase III

GY019

Arm 1: Carboplatin/Taxol x6 cycles, followed by letrozole daily until disease progression

Arm 2: Letrozole daily until disease progression

Phase III