Status:
Recruiting
Disease Site:
Brain
Diagnosis:
- Newly diagnosed Anaplastic or Low Grade Gliomas
Phase:
Official Title:
Phase III Intergroup Study of Radiotherapy with Concomitant and Adjuvant PCV Chemotherapy in Patients with 1p/19q Co-deleted Anaplastic Glioma or Low Grade Glioma
NCT ID:
NCT#00887146
Link to Full Details:
Description:
Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. It is not yet known whether giving radiation with concomitant and adjuvant temozolomide versus radiation with adjuvant PCV is more effective in treating anaplastic glioma or low grade glioma.
Eligibility:
Male and Female – 18 years and older
Inclusion Criteria:
- < 3 months from surgical diagnosis
- ECOG 0-2
- Surgery must be performed > 2 wks prior to registration and have recovered from effects of surgery
Exclusion Criteria:
- HIV + and currently receiving retroviral therapy
- Uncontrolled intercurrent illness
- Prior treatment for CNS neoplasm
Other Info:
Tissue submission for central pathology review is mandatory for all patients prior to registration.