Have you ever wondered if a clinical trial might be right for you? If you have lung cancer, clinical trials can give you access to new treatments that aren’t available yet to everyone. At Oklahoma Cancer Specialists and Research Institute, we currently have several lung cancer clinical trials available, and you may qualify to participate.
Clinical trials help doctors learn about new methods for treating cancer. When you join a clinical trial, you get to try new treatments while helping researchers find better options for future patients. Our team will work with you to determine if a clinical trial is suitable for your situation.
To know if you’re a good fit for a clinical trial, you need to understand what trials are available and who they’re looking for. At OCSRI, we currently have three lung cancer clinical trials that are accepting new patients.
The PRESERVE-003 Study
This study is designed for patients with metastatic non-small cell lung cancer whose disease has progressed after treatment with PD-1/PD-L1 inhibitors. The trial compares gotistobart, an investigational therapy, with docetaxel chemotherapy to determine which provides better outcomes.
You may be eligible if you are 18 or older, and or if your cancer has metastasized to lymph nodes or other organs. Prior treatment must include at least 12 weeks of PD-1/PD-L1 therapy with platinum chemotherapy, or at least two cycles of platinum chemotherapy followed by 12 weeks of PD-1/PD-L1 treatment.
Patients whose tumors have EGFR, ROS1, MET, BRAF, RET, NTRK, ALK, or HER2 mutations are not eligible. However, KRAS mutations do not exclude participation. The treatment protocol involves IV infusions every three weeks for up to 17 cycles, approximately one year.
The AVANZAR Study
This study enrolls patients beginning first-line treatment for advanced non-small cell lung cancer. It compares two different treatment combinations to see which one helps patients live longer and feel better.
Eligibility requires being 18 or older with Stage IIIB, IIIC, or Stage IV non-small cell lung cancer that is not amenable to curative surgery or radiation. You must not have received prior systemic therapy or chemotherapy for advanced disease. Tumors with EGFR mutations, ALK rearrangements, or ROS1 rearrangements are excluded.
A tumor tissue sample is required for biomarker testing. Patients with mixed small-cell and non-small cell histology, or those with certain autoimmune or inflammatory conditions, do not qualify.
The Clinicogenomic Research Study
This observational study investigates how blood-based biomarkers can predict treatment response in patients with metastatic non-small cell lung cancer or extensive-stage small-cell lung cancer who are initiating standard therapy.
If you are 18 or older with one of these diagnoses and plan to begin standard treatment, you may be eligible. Participation involves providing blood samples at the initiation of treatment, at the first imaging assessment, and at the completion of treatment or upon disease progression.
Concurrent enrollment in interventional clinical trials is not permitted.
How Do I Know If I Qualify?
Whether you qualify for a clinical trial depends on several things: what type of cancer you have, how far it has spread, what treatments you’ve already had, and your overall health. Some trials look for people who haven’t had treatment yet, while others are for people whose cancer has grown despite previous treatments.
Your doctor will review your medical history and current health to determine if a trial is right for you. Each trial has specific requirements to ensure participants stay safe and the research yields good results.
Want to Learn More?
If you want to find out whether you might qualify for one of our lung cancer clinical trials, talk to your cancer care team. They can assess your specific situation, explain what participating would involve, and help you determine if it’s a good option for you.
At Oklahoma Cancer Specialists and Research Institute, we’re committed to providing you with the best care possible, including access to innovative treatments through clinical research. Our team is ready to answer your questions and help you understand your options. Contact our team to schedule an appointment and discover if a clinical trial is a suitable option for you.